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CLS Cell Lines Service GmbH
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Crown Bioscience
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Procell Inc
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Korean Cell Line Bank
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Image Search Results
Journal: Oncology Letters
Article Title: NRSN2 promotes breast cancer metastasis by activating PI3K/AKT/mTOR and NF-κB signaling pathways
doi: 10.3892/ol.2019.11152
Figure Lengend Snippet: NRSN2 knockdown suppresses and NRSN2 overexpression increases the proliferation of breast cancer cells in vitro . (A) NRSN2 knockdown decreased NRSN2 expression in MDA-MB-231 cells. (B) NRSN2 overexpression increased NRSN2 expression in MDA-MB-231 cells. (C) NRSN2 knockdown inhibited MDA-MB-231 cell proliferation. (D) NRSN2 overexpression promoted MDA-MB-231 cell proliferation. (E) NRSN2 knockdown inhibited the colony formation of MDA-MB-231 cells. (F) NRSN2 overexpression promoted the colony formation of MDA-MB-231 cells. NC, negative control; NRSN2, neurensin-2; ns, not significant; si, small interfering (RNA); siR-NRSN2, siRNA against NRSN2; pRK5-NRSN2, NRSN2 overexpression vector. **P<0.01.
Article Snippet:
Techniques: Over Expression, In Vitro, Expressing, Negative Control, Small Interfering RNA, Plasmid Preparation
Journal: Oncology Letters
Article Title: NRSN2 promotes breast cancer metastasis by activating PI3K/AKT/mTOR and NF-κB signaling pathways
doi: 10.3892/ol.2019.11152
Figure Lengend Snippet: NRSN2 promotes tumor cell migration and invasion in vitro . NRSN2 overexpression promoted the (A) migration and (B) invasion of MDA-MB-231 cells. NRSN2 knockdown inhibited the (C) migration and (D) invasion of MDA-MB-231 cells. NRSN2, neurensin-2; si, small interfering (RNA); siR-NRSN2, siRNA against NRSN2; pRK5-NRSN2, NRSN2 overexpression vector. **P<0.01.
Article Snippet:
Techniques: Migration, In Vitro, Over Expression, Small Interfering RNA, Plasmid Preparation
Journal: Oncology Letters
Article Title: NRSN2 promotes breast cancer metastasis by activating PI3K/AKT/mTOR and NF-κB signaling pathways
doi: 10.3892/ol.2019.11152
Figure Lengend Snippet: NRSN2 promotes proliferation, migration and invasion of breast cancer cells by activating PI3K/AKT/mTOR and NF-κB signaling pathways. (A) NRSN2 knockdown significantly inhibited the phosphorylation of PI3K, AKT and mTOR in MDA-MB-231 cells. (B) NRSN2 knockdown significantly decreased the levels of IκBα and P65 phosphorylation in MDA-MB-231 cells. Control, PBS-treated cells. NC, negative control; NRSN2, neurensin-2; ns, not significant; p-, phosphorylated; si, small interfering (RNA); si-RNRSN2, siRNA against NRSN2; pRK5-NRSN2, NRSN2 overexpression vector; NF-κBIR, NF-κB inhibitor; PI3KIR, PI3K inhibitor. **P<0.01. NRSN2 promotes proliferation, migration and invasion of breast cancer cells by activating PI3K/AKT/mTOR and NF-κB signaling pathways. (C) NRSN2 overexpression promoted the phosphorylation of PI3K, AKT and mTOR in MDA-MB-231 cells. (D) NRSN2 overexpression promoted the levels of p-IκBα and p-P65 in MDA-MB-231 cells. Control, PBS-treated cells. NC, negative control; NRSN2, neurensin-2; ns, not significant; p-, phosphorylated; si, small interfering (RNA); si-RNRSN2, siRNA against NRSN2; pRK5-NRSN2, NRSN2 overexpression vector; NF-κBIR, NF-κB inhibitor; PI3KIR, PI3K inhibitor. **P<0.01. NRSN2 promotes proliferation, migration and invasion of breast cancer cells by activating PI3K/AKT/mTOR and NF-κB signaling pathways. (E) NF-κBIR inhibited the pro-proliferation effects of NRSN2 in MDA-MB-231 cells. NF-κBIR suppressed the migration (F) and invasion (G) of MDA-MB-231 cells. PI3KIR suppressed NRSN2-promoted (H) proliferation, (I) migration and (J) invasion of MDA-MB-231 cells. Control, PBS-treated cells. NC, negative control; NRSN2, neurensin-2; ns, not significant; p-, phosphorylated; si, small interfering (RNA); si-RNRSN2, siRNA against NRSN2; pRK5-NRSN2, NRSN2 overexpression vector; NF-κBIR, NF-κB inhibitor; PI3KIR, PI3K inhibitor. **P<0.01.
Article Snippet:
Techniques: Migration, Negative Control, Small Interfering RNA, Over Expression, Plasmid Preparation